Brent Tworetzky

What kind of mindset does it take to go from building data systems at Palantir, to leading engineering at Komodo Health, to becoming CEO of Particle Health – and suing one of healthcare’s largest incumbents? Jason Prestinario is a First Builder through and through. As CEO of Particle Health, his mission is to fix patient data interoperability, so your primary care doctor, specialist, and surgeon can all make decisions using the same complete health record. What a concept, right? And yet, it’s far from reality. That’s why Jason and the team at Particle are now suing Epic, one of the industry’s largest incumbents, to push for real change. We talked about how he approaches challenges of this scale, and what keeps him grounded in the process. We sat down with Jason to talk about this and much more. Hope you'll enjoy this spicy and insightful episode! Link in comments 🌶️ 👇

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Talking to users and thoughtfully integrating their needs and wants was woven through everything we did at IDEO—threaded through every prototype and product decision. Reading my colleagues Joanne and Leo's latest work brought that to mind. They describe a future where research runs continuously, with AI agents recruiting participants and instantly surfacing insights. Synthetic personas, carefully trained on consumer signals, mirror human behavior closely enough to extend live studies and compress timelines from weeks to hours. Today user research mostly runs in fits and starts, prohibitively expensive and locked away in dedicated project cycles when it could be a constant companion, seamlessly integrated into the product development process. Joanne and Leo lay out the full vision here: https://lnkd.in/gEUBSG_J

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Product leaders like Ari Hoffman have a saying at work when things happen or are done that make absolutely no sense to anyone on the team: "Because healthcare." Tune in to the latest episode of the Lifers podcast to hear from a physician-turned-product leader on the frontlines, as we discuss everything from why it took so long for hospitals to ditch faxes to the future of employer-sponsored healthcare. Links to the full episode are in the comments. 👇

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GLP-1 medications are reshaping the landscape of metabolic health and beyond. As the science, market, and demand continue to evolve — so does Noom. Our new Microdose GLP-1Rx program expands accessibility with a lower price and reduced side effects while retaining access to our proven habit building techniques that help members achieve sustainable, long-term health results.

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"Product craft" seems to be missing in many consumer-grade product flows I interface with these days. It's wild to see just how many well-known consumer-grade tech products that end up poorly designing something as seemingly simple as an "onboarding flow," which then reduces the "top of funnel" growth these apps need to truly take off and gain virality. Take Two-Factor Auth and Single-Sign On for example. Consumer apps require 2FA, asking users to provide some form of #SSO (Google, Meta Facebook, Instagram, LinkedIn) along with their phone number. This is a huge #painpoint for most, with many prospective users #abandoning their sign-up as the "push isn't worth the shove." On the contrary, the Partiful team has nailed this. While using 1FA, the app outsources #auth #security upstream, as the phone carrier (phone is the only auth method allowed) vets the mobile number on behalf of Partiful by successfully delivering the text. This (along with excellent #events driven marketing), likely helped them get to 500,000 monthly active users in Q1 2025, representing a 400% year-over-year increase #onboarding #growth #productgrowth #productcraft #craft #productsense #2FA #1FA #auth #productdesign

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Excited to launch the TPH Rural Health Transformation Lab. We’re building an open innovation platform to help design scalable healthcare solutions for rural communities, starting with Alaska. Proud to partner with Jonathan Strong, who runs Medicaid-funded care facilities in Kodiak and brings deep operational experience in rural healthcare. Our mission is to bring together innovators, clinicians, and technologists to solve real rural healthcare challenges. If solutions work in frontier environments, they can scale anywhere.

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This week’s newsletter is about turning clinical expertise into real product power with systems-level understanding. If you’re building (or advising) in digital health, this one’s about moving from knowing the problem to designing for reality. https://lnkd.in/g9a3udE7

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Most teams don't struggle with speed anymore. They struggle with building the right things. That's exactly where my brother thrives. He's a Principal Product Designer who brings real product thinking into design. The kind of person who helps teams cut through complexity and focus on what matters. If you're building serious products and need that level of thinking, take a look at his post below.

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