Services
Experience
Education
Licenses & Certifications
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Finance Foundational Series - Enterprise Overview and Corporate Finance Strategy
Prudential Financial
Issued -
Advanced Methods in Data Science and Big Data Analytics
Dell EMC
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Data Science and Big Data Analytics
Dell EMC
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Changing the Culture - Teaching for Inclusion (Teaching Students with Disabilities)
University of Rhode Island
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From Fourier Series to Wavelets - Theory and Applications by The School of Mathematics and Statistics
University of Hyderabad
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Volunteer Experience
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Instructor
Learning Assistance Network at University of Rhode Island
Science and Technology
Taught Mathematics, Statistics, Physics and Computer Science for Undergraduate and Graduate Students
Publications
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Development and comparative assessment of Raman spectroscopic classification algorithms for lesion discrimination in stereotactic breast biopsies with microcalcifications
Journal of Biophotonics
See publicationMicrocalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. Here, we develop and compare different approaches for developing Raman classification algorithms to diagnose invasive and in situ breast cancer, fibrocystic change and fibroadenoma that can be associated with microcalcifications. In this study, Raman spectra were acquired from tissue cores obtained from fresh breast biopsies and analyzed using a constituent-based breast model.…
Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. Here, we develop and compare different approaches for developing Raman classification algorithms to diagnose invasive and in situ breast cancer, fibrocystic change and fibroadenoma that can be associated with microcalcifications. In this study, Raman spectra were acquired from tissue cores obtained from fresh breast biopsies and analyzed using a constituent-based breast model. Diagnostic algorithms based on the breast model fit coefficients were devised using logistic regression, C4.5 decision tree classification, k-nearest neighbor (k -NN) and support vector machine (SVM) analysis, and subjected to leave-one-out cross validation. The best performing algorithm was based on SVM analysis (with radial basis function), which yielded a positive predictive value of 100% and negative predictive value of 96% for cancer diagnosis. Importantly, these results demonstrate that Raman spectroscopy provides adequate diagnostic information for lesion discrimination even in the presence of microcalcifications, which to the best of our knowledge has not been previously reported. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Patents
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Systems and methods for sampling calibration of non-invasive analyte measurements
Issued US US20170127983A1
See patentSystems and methods of the present invention provide a calibration model that requires minimal information compared with prior techniques. These systems and methods represent the first generalized approach for combined treatment of spectroscopic measurements of a dynamic, mass transfer system
with the underlying kinetic model of said system. The technique can be applied to non-invasive glucose monitoring or monitoring of chemical reaction dynamics. -
Raman spectroscopy for detection of glycated analytes
Issued US 20140349337
See patentThe present invention relates to the optical measurement of blood analytes, such as glycated hemoglobin (HbA1c) and serum albumin as a functional metric of mean blood glucose in the diagnosis of diabetic patients. Non-enhanced Raman spectroscopy is employed as the analytical method for quantitative detection of blood analytes. Using processing techniques, non-enzymatic glycosylation (glycation) of the analytes results in measurable and highly reproducible changes in the acquired spectral data…
The present invention relates to the optical measurement of blood analytes, such as glycated hemoglobin (HbA1c) and serum albumin as a functional metric of mean blood glucose in the diagnosis of diabetic patients. Non-enhanced Raman spectroscopy is employed as the analytical method for quantitative detection of blood analytes. Using processing techniques, non-enzymatic glycosylation (glycation) of the analytes results in measurable and highly reproducible changes in the acquired spectral data, which enable the accurate measurements and classification of glycated and unglycated analytes.
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Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis
Issued US US20120302892 A1
See patentA multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
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Portable Raman diagnostic system
Issued US US20120035442 A1
See patentThe present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary…
The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
Courses
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Introduction to Monte Carlo Methods
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Mathematical Methods of Physics I
PHY510
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Mathematical Methods of Physics II
PHY610
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Statistical Physics I
PHY525
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Statistical Physics II
PHY625
Honors & Awards
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Especially Strong Year (ESY) Award at Dun & Bradstreet (2018)
Dun & Bradstreet
Especially Strong Year (ESY) Award in recognition of exceptional performance in 2018. Dun & Bradstreet is committed to recognizing and rewarding team members who execute, deliver results and make a significant impact on our strategy
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Excellence@EMC - EMC Excellence Silver Award at Global Presales vSE Conference
EMC Corporation
The Silver Award is for individuals and teams whose extra efforts exude commitment and demonstrates extraordinary dedication toward the success of the business critical event (vSE Conference), project, or initiative. These achievements will have an obvious, positive impact on business results and customer needs. They may also be characterized by positive cross-functional and/or financial impact.
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Tony B. Academic Award (2012 and 2013)
SLAS
The Tony B. Academic Award honors Tony Beugelsdijk, Los Alamos National Laboratory, an Association for Laboratory Automation (ALA) co-founder who passed away in August, 2009. This award recognizes up-and-coming researchers who have demonstrated outstanding achievement in laboratory science and technology.
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Young Investigator
Bioanalysis Journal
Young Investigator Award recognizes and promotes the work of highly-talented early-career researchers in Bio-Analytics field.
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Junior Research Fellow
Department of Science and Technology, Government of India
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Merit Award for Academic Excellence (Telugu Vignana Paritoshikam)
State Government of Andhra Pradesh
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Student Senator (2002 to 2007)
Graduate Student Association, University of Rhode Island
The Graduate Student Association (GSA) is a government body maintained by and for the graduate students of the University with the purpose of enhancing the academic, intellectual, and social opportunities of its members. Officers and members of the GSA Senate, who are elected annually from the entire graduate student body, distribute GSA funds to graduate students and other qualifying groups, organize social events, and serve as graduate student representatives on University-wide committees.
Test Scores
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GRE Quant
Score: 800/800
Languages
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English
Native or bilingual proficiency
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Telugu
Native or bilingual proficiency
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Hindi
Native or bilingual proficiency
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Sanskrit
Limited working proficiency
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