Jamie Karraker

Fun fact: Brendan, Adni's technical co-founder, was in the second batch of Y Combinator ever. YC S06! He also has a previous successful exit (sold to UnitedHealthcare), patented an AI algorithm before it was cool, and is a published author... NBD! How has the startup ecosystem evolved over the past 20 years? Brendan shares his wisdom below. 💭 #startups #startupfounder #ycombinator #entrepreneur

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What kind of mindset does it take to go from building data systems at Palantir, to leading engineering at Komodo Health, to becoming CEO of Particle Health – and suing one of healthcare’s largest incumbents? Jason Prestinario is a First Builder through and through. As CEO of Particle Health, his mission is to fix patient data interoperability, so your primary care doctor, specialist, and surgeon can all make decisions using the same complete health record. What a concept, right? And yet, it’s far from reality. That’s why Jason and the team at Particle are now suing Epic, one of the industry’s largest incumbents, to push for real change. We talked about how he approaches challenges of this scale, and what keeps him grounded in the process. We sat down with Jason to talk about this and much more. Hope you'll enjoy this spicy and insightful episode! Link in comments 🌶️ 👇

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Too many startups assume: 𝙩𝙝𝙚𝙧𝙚’𝙨 𝙖 𝘾𝙋𝙏 𝙘𝙤𝙙𝙚 → 𝙩𝙝𝙚𝙧𝙚𝙛𝙤𝙧𝙚 𝙩𝙝𝙚𝙧𝙚’𝙨 𝙖 𝙗𝙪𝙨𝙞𝙣𝙚𝙨𝙨. Reality is rarely that linear. Viability tends to unfold in fits and starts, shaped by payer coverage, provider workflows, and the real operational burden behind reliable billing. ⚙️📉 Inspired by Matt Kamen's excellent post on CPT adoption curves & the recent ACCESS discussion, we’re sharing our internal framework: 𝐐𝐮𝐞𝐬𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐀𝐬𝐤 𝐁𝐞𝐟𝐨𝐫𝐞 𝐁𝐞𝐭𝐭𝐢𝐧𝐠 𝐨𝐧 𝐚 𝐍𝐞𝐰 𝐁𝐢𝐥𝐥𝐢𝐧𝐠 𝐂𝐨𝐝𝐞 It goes deeper than payment policy — covering clinical and documentation requirements, enrollment and service mechanics, operational readiness, and the maturity of the CPT pathway. 🧠📋 If you’re evaluating a CPT-driven business model — or working with someone who is — comment “𝘾𝙋𝙏” below + DM me & I’ll share the document. 📄➡️ #startups #HealthcarePolicy #HealthTech #CMMI #ACCESSModel #Medicare #DigitalHealth

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Thrilled to announce that Together Fund is investing in Sentra, alongside a16z speedrun! You track results in Jira. Decisions in Notion. Conversations in Slack. But the reasoning, the debates, trade-offs, and context behind why you chose A over B, disappears into what we call "Dark Matter." A decision made in March looks insane by July because no one remembers the constraints that made it smart. I lived this firsthand at Twitter scaling from 800 to 8,000 employees, and at Google while launching AI Overviews to billions at planet scale. The problem isn't process. Process is compensation for something deeper: organizational amnesia. An organization’s "Systems of Record" doesn’t solve this, they encode it. They store what happened, never why. That's why we are investing in Sentra. Sentra is the always-on collective memory that eliminates organizational amnesia by maintaining accurate context for all members and agents, functioning as an operational nervous system. It connects to every channel where work happens, meetings, Slack, email, code commits, docs, calendars, and treats them not as artifacts to search, but as living signals to synthesize. The fleeting and the permanent, unified into a memory that understands. The founding team is built for this: - Jae Gwan Park (CEO): Product-first founder, memory systems research at UofT and MIT - Ashwin Gopinath (CSO): Former MIT professor, created "Reflexion" (NeurIPS 2023), agents that learn from mistakes, 2x founder - Andrey Starenky (CTO): Early Vapi engineer, ex-IBM, built to process enterprise-scale data firehose Together is an operator-led fund. We invest in problems we've lived. This is one of them. Many congrats Jae, Ashwin and Andrey, we are so excited to partner with you! Read the full thesis: https://lnkd.in/gixj9cE4 Book a demo: https://www.sentra.app/ #OrganizationalMemory #AI #Sentra #TogetherFund #a16z #ContextGraphs

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We at Andreessen Horowitz could not be more thrilled to lead Ease Health's $41M Series A to redefine healthcare’s operating system, unifying intake (CRM), clinical (EHR), and billing (RCM) into a single, AI-native core platform. We’ve seen this operating system playbook succeed in other industries with companies like Toast and ServiceTitan. Healthcare – long burdened by fragmented, legacy software – is ready for the same shift. Ease is starting in behavioral health, and already supports hundreds of providers across inpatient, outpatient (IOP, PHP, MAT), and residential. The team made this decision easy. CEO Zach Cohen has been a friend and colleague at a16z for years, and was someone I knew I’d be extremely lucky to back if ever given the opportunity. CTO Raymond W. is an incredible engineering leader with a track record of building and scaling elite technical teams. And President Steve Gold previously built and sold the behavioral health leader Refresh to Optum for one of the largest exits in the space. We’re proud to partner with Zach, Raymond, and Steve, and to invest alongside Abstract, BoxGroup, Sunflower Capital, and F3 Partners. Check it out: https://easehealth.com Eva Steinman Anish Acharya

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One takeaway that resonates strongly with me is that AI is shifting chronic disease care from reactive visits to proactive, personalized, and continuous support, unlocking tremendous near-term, system-level opportunities for outcome improvement and cost savings.

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Building UIs has never been easier with Tailwind. It turned styling into a productivity superpower and AI amplified that even further. But AI is also slowly breaking the economics behind open source (or at least Tailwind). It’s eating the discovery, traffic, and revenue that made open source sustainable The tools are winning, but the business models aren’t. If we don’t figure it out, we risk losing many tools that built the modern web.

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